Kutina A

Research interests: physiology of the kidneys and water-salt balance, the role of hormones of the neurohypophysis and the gastrointestinal tract for the regulation of ion balance. A number of synthetic analogues of neurohypophysis hormones were studied and the dependence of the structure of these peptides and their natriuretic, kaliuretic and antidiuretic activities was revealed, indicating the possibility of highly selective regulation of sodium and potassium excretion by the kidney with the participation of vasopressin and oxytocin. The homeostatic role of glucagon-like peptide-1 in maintaining the ion balance is demonstrated and the mechanism of its effects on the effectiveness of the water-salt balance regulators acting in the distal nephron is studied. Research skills: physiological experiments on animals, clearance methods, flame photometry, atomic absorption spectrophotometry, biochemical and enzyme immunoassay, statistical and graphical analysis of experimental data.