Dubrovskaya N
Dubrovskaya
Nadehzda M.
PhD
OrcID: 0000-0002-4414-6883
ResearcherID: AAN-1024-2020
Research Gate: Nadezhda-Dubrovskaya
Scopus ID: 6602818468
eLibrary ID: 122799
E-Mail: ndub@iephb.ru
There are possession of methods of analysis of movement behavior, cognitive and olfactory functions in ontogenesis, as well as surgical operations to implant injection cannulas into the brain. The scientific work is devoted to the study of the central mechanisms of cognitive functions in animals with normal and pathological embryogenesis, special attention is paid to the study of the participation of amyloid peptide metabolism enzymes in learning and memory processes. It has been established that the impact of a pathogenic factor during the period when when the processes of neuroblasts generation and migration predominate in the brain affects both the physiological development and formation of motor behavior of animals, as well as the realization of cognitive functions, while the period when the processes of maturation and differentiation predominate in the brain affects only realization of cognitive functions. It was shown that the observed cognitive impairment can be corrected by administration of certain pharmacological substances into the organism at different stages of ontogenesis.
Monographs and chapters
Zhuravin I, Dubrovskaya N, Tumanova N, Vasiliev D, Nalivaeva N / Ontogenetic and phylogenetic approaches for studying the mechanisms of cognitive dysfunctionsdysfunctions // Evolutionary Physiology and Biochemistry: Advances and Perspectives / ed. V.F. Levchenko / Rijeka, Croatia / Intech / 2018 / Ch. 15
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Articles
Postnikova T, Griflyuk A, Tumanova N, Dubrovskaya N, Mikhel A, Vasiliev D, Zaitsev A / Prenatal Hyperhomocysteinemia Leads to Synaptic Dysfunction and Structural Alterations in the CA1 Hippocampus of Rats / Biomolecules 2025 108(2) : 305
DOIPubMed
DOIPubMed
Vasiliev D, Tumanova N, Dubrovskaya N, Pakhomov K, Sobolev V / The Effect of Administration of a Low Dose of 2,3,7,8- Tetrachlorodibenzo-P-Dioxin To Pregnant Rats on the Ultrastructure of the Parietal Cortex and Neurodevelopmental Behavior of the Offspring in Early Ontogenesis / J Evol Biochem Phys+ 2025 61(6) : 1757–1765
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Postnikova T, Griflyuk A, Tumanova N, Dubrovskaya N, Mikhel A, Vasiliev D, Zaitsev A / Prenatal Hyperhomocysteinemia Leads to Synaptic Dysfunction and Structural Alterations in the CA1 Hippocampus of Rats / Biomolecules 2025 5(2) : 305
DOIPubMedwww
DOIPubMedwww
Tumanova N, Vasiliev D, Dubrovskaya N, Nalivaeva N / Structural and ultrastructural organization of the parietal cortex and dorsal hippocampus in transgenic 5xFAD mice administered sodium valproate, a histone deacetylase inhibitor / Veterinary Science Development 2025 9(1) : 10639
DOIeLibrary
DOIeLibrary
Vasiliev D, Shcherbitskaia A, Tumanova N, Mikhel A, Milyutina Y, Kovalenko A, Dubrovskaya N, Inozemtseva D, Zalozniaia I, Arutjunyan A / Hyperhomocysteinemia Disturbs the Mechanisms of Embryonic Brain Development and Its Maturation in Early Postnatal Ontogenesis / Cells 2023 12(1) : 189
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Vasiliev D, Dubrovskaya N, Tumanova N, Nalivaeva N / Analysis of Expression of the Amyloid-Degrading Enzyme Neprilysin in Brain Structures of 5xFAD Transgenic Mice / J Evol Biochem Physiol 2022 8(1) : 157–169
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Tumanova N, Vasiliev D, Dubrovskaya N, Nalivaeva N / Morphofunctional Changes in the Brain Tissue of 5xFAD Transgenic Mice / Cell and Tissue Biology 2022 16(2) : 380–391
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Tumanova N, Vasiliev D, Dubrovskaya N, Nalivaeva N / Neurodegenerative Changes in the Structural and Ultrastructural Organization in the Pyriform Cortex of 5xFAD Transgenic Mice / J Evol Biochem Physiol. 2022 10(4) : 1225-1239
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Vasiliev D, Dubrovskaya N, Nalivaeva N / Caspase Inhibition Restores NEP Expression and Rescues Olfactory Deficit in Rats Caused by Prenatal Hypoxia / J Mol Neurosci 2022 438(7) : 1516-1526
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Amakhin D, Soboleva E, Postnikova T, Tumanova N, Dubrovskaya N, Kalinina D, Vasiliev D / Maternal Hypoxia Increases the Excitability of Neurons in the Entorhinal Cortex and Dorsal Hippocampus of Rat Offspring. / // Front. Neurosci 2022 16 : 867120
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Sokolov A, Dubrovskaya N, Kostevich V, Vasiliev D, Voynova I, Zakharova E, Runova O, Semak I, Budevich A, Nalivaeva N, Vasilyev V / Lactoferrin Induces Erythropoietin Synthesis and Rescues Cognitive Functions in the Offspring of Rats Subjected to Prenatal Hypoxia / Nutrients 2022 14 : 1399
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Postnikova T, Amakhin D, Trofimova A, Tumanova N, Dubrovskaya N, Kalinina D, Kovalenko A, Shcherbitskaya A, Vasiliev D, Zaitsev A / Maternal Hyperhomocysteinemia Produces Memory Deficits Associated with Impairment of Long-Term Synaptic Plasticity in Young Rats / Cells 2022 12(1) : 58
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Vasiliev D, Dubrovskaya N, Zhuravin I, Nalivaeva N / Developmental Profile of Brain Neprilysin Expression Correlates with Olfactory Behaviour of Rats / Journal of Molecular Neuroscience 2021 71(9) : 1772-1785
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Tumanova N, Vasiliev D, Dubrovskaya N, Nalivaeva N, Zhuravin I / Effect of Prenatal Hypoxia on Cytoarchitectonics and Ultrustructural Organisation of Brain Regions Related to Olfaction in Rats / Cell and Tissue Biology 2021 4(5) : 482-492
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Nalivaeva N, Vasiliev D, Dubrovskaya N, Turner A, Zhuravin I / Role of neprilysin in synaptic plasticity and memory / Ross Fiziol Zh Im I M Sechenova 2020 1069(10) : 1191-1208
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Zhuravin I, Dubrovskaya N, Vasiliev D, Kozlova D, Kochkina E, Tumanova N, Nalivaeva N / Regulation of Neprilysin Activity and Cognitive Functions in Rats After Prenatal Hypoxia / Neurochemical Research 2019 44(6) : 1387-1398
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Zhuravin I, Dubrovskaya N, Vasiliev D, Postnikova T, Zaitsev A / Prenatal hypoxia produces memory deficits associated with impairment of long-term synaptic plasticity in young rats / Neurobiology of learning and memory 2019 P. : 1-10
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Kozlova D, Kochkina E, Dubrovskaya N, Zhuravin I / Effect of Prenatal Hypoxia on Cholinesterase Activity in Blood Serum of Rats / Neurochemical Journal 2018 April. 12(2) : 159–167
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Tikhonravov D, Dubrovskaya N, Zhuravin I / The Notions of Size and Shape in Old World Monkeys (Macaca mullata): A Comparative Analysis of the Formation Process. / Journal of Evolutionary Biochemistry and Physiology 2018 54(3) : 234—241
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Zhuravin I, Dubrovskaya N, Tumanova N, Vasiliev D, Nalivaeva N / Ontogenetic and phylogenetic approaches for studying the mechanisms of cognitive dysfunctions / Evolutionary Physiology and Biochemistry: Advances and Perspectives / ed. V.F. Levchenko. InTech: Rijeka, Croatia. 2018 Ch. 15 : 205-224
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Tumanova N, Vasiliev D, Dubrovskaya N, Zhuravin I / Ultrastructural alterations in the sensorimotor cortex upon delayed development of motor behavior in early ontogenesis of rats exposed to the prenatal hypoxia / Cell and Tissue Biology 2018 12(5) : 419-425
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Dubrovskaya N, Tikhonravov D, Alekseeva O, Zhuravin I / Recovery of learning and memory impaired by prenatal hypoxic stress in rats after injection of caspase-3 inhibitor during early ontogenesis / Journal of Evolutionary Biochemistry and Physiology 2017 53(1) : 66-68
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Vasiliev D, Dubrovskaya N, Tumanova N, Zhuravin I / Prenatal hypoxia in different periods of embryogenesis differentially affects cell migration, neuronal plasticity and rat behavior in postnatal ontogenesis / Frontiers in Neuroscience 2016 10 : 126
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Vasiliev D, Dubrovskaya N, Nalivaeva N, Zhuravin I / Regulation of Caspase-3 Content and Activity in Rat Cortex in Norm and after Prenatal Hypoxia / Neurochemical Journal 2016 10(2) : 144–150
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Vasiliev D, Dubrovskaya N, Tumanova N, Zhuravin I / Prenatal Hypoxia in Different Periods of Embryogenesis Differentially Affects Cell Migration, Neuronal Plasticity, and Rat Behavior in Postnatal Ontogenesis / Frontiers in Neuroscience 2016 38
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Kozlova D, Vasiliev D, Dubrovskaya N, Nalivaeva N, Tumanova N, Zhuravin I / Role of caspase-3 in regulation of the amyloid-degrading neuropeptidase neprilysin level in the rat cortex after hypoxia / Journal of Evolutionary Biochemistry and Physiology 2015 51(6) : 480-484
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Zhuravin I, Dubrovskaya N, Vasiliev D, Kozlova D, Tumanova N, Turner A, Nalivaeva N / Role of caspase-3 in development of neuronal plasticity and memory / SpringerPlus 2015 June 12; 4(1) : P57
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Kalinina D, Frolova E, Lavrentjeva V, Dubrovskaya N, Lukomskaya N, Kim K, Zaitsev A, Zhuravin I, Magazanik L / Delayed effect of prenatal exposure to hypoxia on the susceptibility of rats to electric seizures / Dokl. Biol. Sci. 2015 Nov;465(1) : 271-3
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