Sibarov D

Sibarov D

Sibarov

Dmitry 

PhD

OrcID:  0000-0002-2224-2145
ResearcherID:  K-8551-2012
Research Gate:  Dmitry_Sibarov
Scopus ID:  6603140406
eLibrary ID:  141788
E-Mail:  dsibarov@iephb.ru
WEB: http://sibarov.ru

My main scientific interests are linked with neuronal pathological states, especially excitotoxicity. It is a term that describes the neuronal death caused by neurotoxic effects of glutamate, which is the most abundant excitatory neurotransmitter in the vertebrate central nervous system.

Glutamate is well known to be involved in cognitive functions like learning and memory, but its excessive accumulation in extracellular space can lead to neuronal damages and eventual cell death via necrosis and apoptosis. As a result excitotoxicity contributes to pathogenesis of numerous neurodegenerative diseases. The study in this area can possibly provide new directions in selective therapy of neurodegenerative states.

The main methods in our laboratory are confocal microscopy and patch-clamp electrophysiology in primary neuronal cortical culture.

Articles

Stepanenko Yu, Sibarov D, Antonov S / Regulatory Ouabain Action on Excitatory Transmission in Rat Hippocampus: Facilitation of Synaptic Responses and Weakening of LTP / Biomolecules 2025 15(9) : 1236
DOIPubMed
Boikov S, Sibarov D / Revealing the Direct Modulation of Sodium-Calcium Exchanger by Na/K-ATPase in Cortical Neurons / J Evol Biochem Phys+ 2025 61(5-6) : 1997–2004
DOIeLibrary
Sibarov D, Boikov S, Karelina T, Ushko V, Fyodorina A, Antonov S / Comparative Study on Modulation of Synchronized Neuronal Activity by SK Channels and Na/K-ATPase / Int. J. Mol. Sci. 2025 26(20) : 10004
DOIPubMed
Antonov S, Sibarov D / Evaluation and experimental monitoring of calcium in plasma membrane inner nanoscale cytoplasm regions / Commun Biol 2025 8(1) : 1829
DOIPubMed
Sibarov D, Zhuravleva Z, Ilyina M, Boikov S, Stepanenko Yu, Karelina T, Antonov S / Unveiling the Role of Cholesterol in Subnanomolar Ouabain Rescue of Cortical Neurons from Calcium Overload Caused by Excitotoxic Insults / Cells 2023 12(15) : 2011
DOIPubMed
Stepanenko Yu, Sibarov D, Shestakova N, Antonov S / Tricyclic Antidepressant Structure-Related Alterations in Calcium-Dependent Inhibition and Open-Channel Block of NMDA Receptors / Front Pharmacol 2022 12 : 815368
DOIPubMed
Boikov S, Sibarov D, Stepanenko Yu, Karelina T, Antonov S / Calcium-Dependent Interplay of Lithium and Tricyclic Antidepressants, Amitriptyline and Desipramine, on N-methyl-D-aspartate Receptors / Int J Mol Sci 2022 23(24) : 16177
DOIPubMed
Boikov S, Sibarov D, Antonov S / Nutritional and Metabolic Factors, Ethanol and Cholesterol, Interact With Calcium-Dependent N-Methyl-D-Aspartate Receptor Inhibition by Tricyclic Antidepressants / Front Cell Neurosci 2022 16 : 946426
DOI
Boikov S, Sibarov D, Karelina T, Shestakova N, Antonov S / The Role of Ryanodine and IP3-receptors in Calcium Responses to Tricyclic Antidepressants in Rat Neocortical Neurons / J Evol Biochem Phys 2021 57 : 694–703
DOI
Boikov S, Sibarov D, Antonov S / Ethanol inhibition of NMDA receptors in calcium-dependent and -independent modes / Biochem Biophys Res Commun. 2020 Feb 19; 522(4) : 1046-1051
DOIPubMed
Ivanova M, Kokorina A, Timofeeva P, Karelina T, Abushik P, Stepanenko Yu, Sibarov D, Antonov S / Cascades Contribute to Ouabain Neuroprotection in Hyperhomocysteinemia / Biomolecules 2020 10(8) : E1104
DOI
Sibarov D, Boikov S, Karelina T, Antonov S / GluN2 subunit-dependent redox modulation of NMDA receptor activation by homocysteine / Biomolecules 2020 10(10) : 1441
DOI
Stepanenko Yu, Boikov S, Sibarov D, Abushik P, Vanchakova N, Belinskaia D, Shestakova N, Antonov S / Dual action of amitriptyline on NMDA receptors: enhancement of Ca-dependent desensitization and trapping channel block / Sci Rep 2019 Dec 19; 9(1) : 19454
DOIPubMedwww
Sibarov D, Giniatullin R, Antonov S / High sensitivity of cerebellar neurons to homocysteine is determined by expression of GluN2C and GluN2D subunits of NMDA receptors. / Biochem Biophys Res Commun. 2018 Nov 30;506(3) : 648-652
DOIPubMed
Sibarov D, Poguzhelskaya E, Antonov S / Downregulation of calcium-dependent NMDA receptor desensitization by sodium-calcium exchangers: a role of membrane cholesterol. / BMC Neurosci 2018 Nov 12;19(1) : 73
DOIPubMed
Sibarov D, Stepanenko Yu, Silantiev I, Abushik P, Karelina T, Antonov S / Developmental Changes of Synaptic and Extrasynaptic NMDA Receptor Expression in Rat Cerebellar Neurons In Vitro. / J Mol Neurosci 2018 Feb; 64(2) : 300-311
DOIPubMed
Sibarov D, Bruneau N, Antonov S, Szepetowski P, Burnashev N, Giniatullin R / Functional Properties of Human NMDA Receptors Associated with Epilepsy-Related Mutations of GluN2A Subunit. / Front Cell Neurosci 2017 May 29; 11 : 155
DOIPubMed
Abushik P, Bart G, Korhonen P, Leinonen H, Giniatullina R, Sibarov D, Levonen A, Malm T, Antonov S, Giniatullin R / Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling. / Cephalalgia 2017 Dec;37(14) : 1373-1383
DOIPubMed
Sibarov D, Abushik P, Giniatullin R, Antonov S / GluN2A Subunit-Containing NMDA Receptors Are the Preferential Neuronal Targets of Homocysteine. / Front Cell Neurosci 2016 Nov 1; 10 : 246
DOIPubMed
Sibarov D, Abushik P, Poguzhelskaya E, Bolshakov K, Antonov S / Inhibition of Plasma Membrane Na/Ca-Exchanger by KB-R7943 or Lithium Reveals Its Role in Ca-Dependent N-methyl-d-aspartate Receptor Inactivation. / J Pharmacol Exp Ther. 2015 Dec;355(3) : 484-95
DOIPubMed

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