Shestakova N
Natalia Shestakova, PhD in Biology, Senior Researcher, has 20 years of experience in studying the mechanisms of treatment of neuropathic pain and pruritus using molecular modeling methods. She is the author of 50 publications and 2 patents. With the support of 2 grants from the Russian Foundation for Basic Research, 2 grants the Presidium of the Academy of Sciences, and 2 grants from the Government of St. Petersburg, she directs researches in the field of studying the molecular mechanisms of relieving neuropathic pain and itching, based on the results of which the adjuvant analgesic and antipruritic therapies for patients with diabetes mellitus and chronic renal failure have been developed and introduced into clinical practice.
Articles
Andreeva-Gateva P, Hristov M, Strokova-Stoilova M, Ivanova N, Sabit Z, Surcheva S, Beliakov M, Karakashev G, Sukhov I, Belinskaia D, Shestakova N / Therapeutic potential of orally applied KB-R7943 in streptozotocin-induced neuropathy in rats / Heliyon. 2024 10(6) : e27367
DOIPubMed
DOIPubMed
Belinskaia D, Shestakova N / Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data / Biochemistry Moscow 2024 89 : 507–522
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DOI
Stepanenko Yu, Sibarov D, Shestakova N, Antonov S / Tricyclic Antidepressant Structure-Related Alterations in Calcium-Dependent Inhibition and Open-Channel Block of NMDA Receptors / Front Pharmacol 2022 12 : 815368
DOIPubMed
DOIPubMed
Belinskaia D, Savelieva E, Karakashev G, Orlova O, Leninskii M, Khlebnikova N, Shestakova N, Kiskina A / Investigation of Bemethyl Biotransformation Pathways by Combination of LC-MS/HRMS and In Silico Methods / Int J Mol Sci. 2021 22(16) : 9021
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Boikov S, Sibarov D, Karelina T, Shestakova N, Antonov S / The Role of Ryanodine and IP3-receptors in Calcium Responses to Tricyclic Antidepressants in Rat Neocortical Neurons / J Evol Biochem Phys 2021 57 : 694–703
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Uniyal A, Shantanu P, Vaidya S, Belinskaia D, Shestakova N, Kumar R, Singh S, Tiwari V / Tozasertib Attenuates Neuropathic Pain by Interfering with Aurora Kinase and KIF11 Mediated Nociception / ACS Chem Neurosci 2021 12(11) : 1948-1960
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Belinskaia D, Savelieva E, Karakashev G, Orlova O, Leninskii M, Khlebnikova N, Shestakova N, Kiskina A / Investigation of Bemethyl Biotransformation Pathways by Combination of LC–MS/HRMS and In Silico Methods / International Journal of Molecular Sciences 2021 22(16) : 9021
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Belinskaia D, Belinskaia M, Barygin O, Vanchakova N, Shestakova N / Psychotropic drugs for the management of chronic pain and itch / Pharmaceuticals (Basel) 2019 12(2) : 99
DOIwww
DOIwww
Stepanenko Yu, Boikov S, Sibarov D, Abushik P, Vanchakova N, Belinskaia D, Shestakova N, Antonov S / Dual action of amitriptyline on NMDA receptors: enhancement of Ca-dependent desensitization and trapping channel block / Sci Rep 2019 Dec 19; 9(1) : 19454
DOIPubMedwww
DOIPubMedwww
Barygin O, Nagaeva E, Tikhonov D, Belinskaia D, Vanchakova N, Shestakova N / Inhibition of the NMDA and AMPA receptor channels by antidepressants and antipsychotics / Brain Research 2017 1660 : 58-66
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