Тихонов Д. Б.
Тихонов
Денис Борисович
чл.-корр. РАН
OrcID: 0000-0001-8523-4305
ResearcherID: AAK-9148-2020
Research Gate: Denis-Tikhonov
Scopus ID: 7006659210
eLibrary ID: 83060
E-Mail: denistikhonov2002@yahoo.com
Изучение строения и молекулярной фармакологии ионных каналов. Разработка структур новых лигандов и исследование механизмов их действия. Методы молекулярного моделирования и patch clamp.
Статьи
Nikolaev M, Chizhov A, Tikhonov D / Molecular mechanisms of action determine inhibition of paroxysmal depolarizing shifts by NMDA receptor antagonists in rat cortical neurons / Neuropharmacology 2021 184 : 108-443
DOIPubMed
DOIPubMed
Dron M, Zhigulin A, Tikhonov D, Barygin O / Screening for Activity Against AMPA Receptors Among Anticonvulsants — Focus on Phenytoin / Front. Pharmacol. 2021 12 : 775040
DOI
DOI
Tikhonov D, Zhorov B / Crystal and Cryo-EM Structures of P-loop Channels with Drugs / IJMS 2021 22 : 8143
DOI
DOI
Tikhonov D, Zhorov B / Computational Analysis of the Crystal and Cryo-EM Structures of P-Loop Channels with Drugs / International Journal of Molecular Sciences 2021 22(15) : 8143
DOI
DOI
Nikolaev M, Strashkov D, Ryazantsev M, Tikhonov D / Optical Control of N-Methyl- d -aspartate Receptors by Azobenzene Quaternary Ammonium Compounds / ACS Chem Neurosci 2021 Sep 15; 12(18) : 3347-3357
DOIPubMed
DOIPubMed
Tikhonov D, Zhorov B / Intersegment contacts determine geometry of the open and closed states in P-loop channels / J Biomol Struct Dyn. 2020 38(4) : 1012-1027
DOI
DOI
Tikhonov D, Zhorov B / The pore domain in glutamate-gated ion channels: structure, drug binding and similarity with potassium channels / BBA-biomembranes 2020 1862(10) : 183401
DOI
DOI
Tikhonov D, Lin L, Yang D, Yuchi Z, Zhorov B / Phenylalkylamines in calcium channels: Computational analysis of experimental structures / J Computer-Aided Mol Design 2020 34(11) : 1157-1169
DOI
DOI
Tikhonov D, Zhorov B / Molecular modeling in studies of ion channels and their modulation by ligands / Russian J. Physiol. 2019 105 : 1333–1348
DOI
DOI
Finol-Urdaneta R, McArthur J, Gaudet R, Tikhonov D, Zhorov B, French R / Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated Na+ channels / J. Gen. Physiol. 2019 151(2) : 186-199
DOIPubMed
DOIPubMed
Finol-Urdaneta R, McArthur J, Korkosh V, Huang S, McMaster D, Glavica R, Tikhonov D, Zhorov B, French R / Extremely high-affinity block of bacterial voltage-gated sodium channels by µ-conotoxin PIIIA / Marine Drugs 2019 17 : 510
DOIPubMed
DOIPubMed
Shteinikov V, Potapjeva N, Gmiro V, Tikhonov D / Hydrophobic Amines and Their Guanidine Analogues Modulate Activation and Desensitization of ASIC3 / International Journal of Molecular Sciences 2019 20(7) : E1713
DOI
DOI
Nikolaev M, Komarova M, Tikhonova T, Korosteleva A, Potapjeva N, Tikhonov D / Modulation of Proton-Gated Channels by Antidepressants / ACS Chem Neurosci 2019 Mar 20; 10(3) : 1636-1648
DOI
DOI
Du Y, Tikhonov D, Nomura Y, Dong K, Zhorov B / Mutational analysis of state-dependent contacts in the pore module of eukaryotic sodium channels / Arch Biochem Biophys. 2018 652 : 59-79
DOI
DOI
Fehrentz T, Huber F, Vrielink N, Bruegmann T, Frank J, Fine N, Malan D, Danzl D, Tikhonov D, Hell S, Sasse P, Hodson D, Zhorov B, Klöcker N, Trauner D / Optical control of L-type Ca2+ channels using a diltiazem photoswitch / Nature Chem Biol 2018 14 : 764-767
DOIPubMed
DOIPubMed
Tikhonov D, Zhorov B / Predicting structural details of the sodium channel pore basing on animal toxin studies / Frontiers Pharmacol 2018 9(880) : 1-14
DOIPubMed
DOIPubMed
Barygin O, Nagaeva E, Tikhonov D, Belinskaia D, Vanchakova N, Shestakova N / Inhibition of the NMDA and AMPA receptor channels by antidepressants and antipsychotics / Brain Research 2017 1660 : 58-66
DOI
DOI
Tikhonov D, Zhorov B / Mechanism of sodium channel block by local anesthetics, antiarrhythmics and anticonvulsants / J Gen Physiol. 2017 149 : 465-481
DOIPubMed
DOIPubMed
Tikhonov D, Zhorov B / Conservation and variability of the pore-lining helices in P-loop channels / Channels 2017 11(6) : 660-67
DOI
DOI
Nikolaev M, Dorofeeva N, Komarova M, Korolkova Yu, Andreev Ya, Mosharova I, Grishin E, Tikhonov D, Kozlov S / TRPV1 activation power can switch an action mode for its polypeptide ligands / PLOS One 2017 12(5) : e0177077
DOI
DOI
Barygin O, Komarova M, Tikhonova T, Korosteleva A, Nikolaev M, Magazanik L, Tikhonov D / Complex action of tyramine, tryptamine and histamine on native and recombinant ASICs / Channels (Austin) 2017 Nov 2; 11(6) : 648-659
DOI
DOI
Barygin O, Komarova M, Tikhonova T, Tikhonov D / Non-classical mechanism of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor channel block by fluoxetine / Eur J Neurosci 2015 Apr; 41(7) : 869-77
DOI
DOI
Malkin S, Kim K, Tikhonov D, Magazanik L, Zaitsev A / Statistical models suggest presence of two distinct subpopulations of miniature EPSCs in fast-spiking interneurons of rat prefrontal cortex / Neuroscience 2015 301 : 508–519
DOI
DOI