Тихонов Д. Б.

Тихонов Д. Б.

Тихонов

Денис Борисович

чл.-корр. РАН

ResearcherID:  AAK-9148-2020
Research Gate:  Denis-Tikhonov
Scopus ID:  7006659210
eLibrary ID:  83060
Телефон:  +7 , +7 (921) 633-34-73

Изучение строения и молекулярной фармакологии ионных каналов. Разработка структур новых лигандов и исследование механизмов их действия. Методы молекулярного моделирования и patch clamp.

Статьи

Nikolaev M, Chizhov A, Tikhonov D / Molecular mechanisms of action determine inhibition of paroxysmal depolarizing shifts by NMDA receptor antagonists in rat cortical neurons / Neuropharmacology 2021 184 : 108-443
DOIPubMed
Dron M, Zhigulin A, Tikhonov D, Barygin O / Screening for Activity Against AMPA Receptors Among Anticonvulsants — Focus on Phenytoin / Front. Pharmacol. 2021 12 : 775040
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Tikhonov D, Zhorov B / Crystal and Cryo-EM Structures of P-loop Channels with Drugs / IJMS 2021 22 : 8143
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Tikhonov D, Zhorov B / Computational Analysis of the Crystal and Cryo-EM Structures of P-Loop Channels with Drugs / International Journal of Molecular Sciences 2021 22(15) : 8143
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Nikolaev M, Strashkov D, Ryazantsev M, Tikhonov D / Optical Control of N-Methyl- d -aspartate Receptors by Azobenzene Quaternary Ammonium Compounds / ACS Chem Neurosci 2021 Sep 15; 12(18) : 3347-3357
DOIPubMed
Tikhonov D, Zhorov B / Intersegment contacts determine geometry of the open and closed states in P-loop channels / J Biomol Struct Dyn. 2020 38(4) : 1012-1027
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Tikhonov D, Zhorov B / The pore domain in glutamate-gated ion channels: structure, drug binding and similarity with potassium channels / BBA-biomembranes 2020 1862(10) : 183401
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Tikhonov D, Lin L, Yang D, Yuchi Z, Zhorov B / Phenylalkylamines in calcium channels: Computational analysis of experimental structures / J Computer-Aided Mol Design 2020 34(11) : 1157-1169
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Tikhonov D, Zhorov B / Molecular modeling in studies of ion channels and their modulation by ligands / Russian J. Physiol. 2019 105 : 1333–1348
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Finol-Urdaneta R, McArthur J, Gaudet R, Tikhonov D, Zhorov B, French R / Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated Na+ channels / J. Gen. Physiol. 2019 151(2) : 186-199
DOIPubMed
Finol-Urdaneta R, McArthur J, Korkosh V, Huang S, McMaster D, Glavica R, Tikhonov D, Zhorov B, French R / Extremely high-affinity block of bacterial voltage-gated sodium channels by µ-conotoxin PIIIA / Marine Drugs 2019 17 : 510
DOIPubMed
Shteinikov V, Potapjeva N, Gmiro V, Tikhonov D / Hydrophobic Amines and Their Guanidine Analogues Modulate Activation and Desensitization of ASIC3 / International Journal of Molecular Sciences 2019 20(7) : E1713
DOI
Nikolaev M, Komarova M, Tikhonova T, Korosteleva A, Potapjeva N, Tikhonov D / Modulation of Proton-Gated Channels by Antidepressants / ACS Chem Neurosci 2019 Mar 20; 10(3) : 1636-1648
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Du Y, Tikhonov D, Nomura Y, Dong K, Zhorov B / Mutational analysis of state-dependent contacts in the pore module of eukaryotic sodium channels / Arch Biochem Biophys. 2018 652 : 59-79
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Fehrentz T, Huber F, Vrielink N, Bruegmann T, Frank J, Fine N, Malan D, Danzl D, Tikhonov D, Hell S, Sasse P, Hodson D, Zhorov B, Klöcker N, Trauner D / Optical control of L-type Ca2+ channels using a diltiazem photoswitch / Nature Chem Biol 2018 14 : 764-767
DOIPubMed
Tikhonov D, Zhorov B / Predicting structural details of the sodium channel pore basing on animal toxin studies / Frontiers Pharmacol 2018 9(880) : 1-14
DOIPubMed
Barygin O, Nagaeva E, Tikhonov D, Belinskaia D, Vanchakova N, Shestakova N / Inhibition of the NMDA and AMPA receptor channels by antidepressants and antipsychotics / Brain Research 2017 1660 : 58-66
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Tikhonov D, Zhorov B / Mechanism of sodium channel block by local anesthetics, antiarrhythmics and anticonvulsants / J Gen Physiol. 2017 149 : 465-481
DOIPubMed
Tikhonov D, Zhorov B / Conservation and variability of the pore-lining helices in P-loop channels / Channels 2017 11(6) : 660-67
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Nikolaev M, Dorofeeva N, Komarova M, Korolkova Yu, Andreev Ya, Mosharova I, Grishin E, Tikhonov D, Kozlov S / TRPV1 activation power can switch an action mode for its polypeptide ligands / PLOS One 2017 12(5) : e0177077
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Barygin O, Komarova M, Tikhonova T, Korosteleva A, Nikolaev M, Magazanik L, Tikhonov D / Complex action of tyramine, tryptamine and histamine on native and recombinant ASICs / Channels (Austin) 2017 Nov 2; 11(6) : 648-659
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Barygin O, Komarova M, Tikhonova T, Tikhonov D / Non-classical mechanism of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor channel block by fluoxetine / Eur J Neurosci 2015 Apr; 41(7) : 869-77
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Malkin S, Kim K, Tikhonov D, Magazanik L, Zaitsev A / Statistical models suggest presence of two distinct subpopulations of miniature EPSCs in fast-spiking interneurons of rat prefrontal cortex / Neuroscience 2015 301 : 508–519
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