Proskurina E

The main direction of my research in recent years has been the study of the interaction of different types of neurons in the entorhinal cortex and hippocampus of mice in health and disease. The mechanisms of the generation and cessation of ictal activity in slices of the entorhinal cortex and hippocampus were studied in the 4-aminopyridine model of epileptiform activity using electrophysiology, optogenetics and mathematical modeling. It has recently been shown that the onset of the first ictal discharge in the 4-aminopyridine model is preceded by a state of depolarization block of fast-spiking interneurons (material in preparation for publication). It has previously been shown using optogenetics that specific low-frequency stimulation of principal (excitatory) neurons, but not interneurons, has an antiepileptic effect in the 4-aminopyridine model (Proskurina et al., 2022, doi: 10.3390/ijms24010195).