Nikolaev M
Nikolaev
Maxim V
PhD
OrcID: 0000-0001-6501-7143
ResearcherID: AAM-9380-2020
Research Gate: Maxim_Nikolaev
Scopus ID: 57220065989
eLibrary ID: 909916
E-Mail: maxim.nikolaev@eiphb.ru
Dr. Maxim V. Nikolaev studies the basics of synaptic transmission and plasticity. Of particular interest are ion channels that provide synaptic communication between neurons. Dr. Nikolaev uses modern electrophysiological, molecular, optical and pharmacological approaches to study the structures, functions and regulation of ion channels. A new area of research is the development of photosensitive modulators of glutamate ionotropic receptors. These compounds quickly and reversibly control the activity of ion channels, which is necessary for a detailed study of the central nervous system in normal and pathological conditions.
Articles
Nikolaev M, Fedorova I, Chistyakova O, Postnikova T, Kim K, Dron M, Zaitsev A, Tikhonov D / Dual Mechanisms of the Diazepine-Benzimidazole Derivative, DAB-19, in Modulating Glutamatergic Neurotransmission / Int J Mol Sci 2025 26(11) : 5299
DOIPubMed
DOIPubMed
Nikolaev M, Gataulina E, Fedorova I, Baleeva N, Baranov M, Vassilevski A, Tikhonov D / Optical control of calcium-permeable AMPA receptors by azobenzene–spermines / Brit J Pharmacol 2025 182(21) : 70111
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DOIPubMed
Evlanenkov K, Nikolaev M, Tikhonov D, Potapieva NN / Temperature-Dependence of ASIC1a Tachyphylaxis / J Evol Biochem Phys+ 2025 61(6) : 2034–2040
DOIeLibrary
DOIeLibrary
Daniil IRudik, Alexander YuSmirnov, Yulia ABogdanova, Andrey AMikhaylov, Alexander RRomanenko, Alexander AKorlyukov, Nikolaev M, Mikhail SBaranov, Dmitrii SIvanov / A photochemical HAT approach to synthesize N-substituted benzoxazin-4-ones and their activity as AMPA receptor modulators / Org Biomol Chem 2025 24(3) : 651-658
DOIPubMed
DOIPubMed
Noev A.N. , Kovalenko S. G., Gataulina E, Turchaninova E. A, Dzhabrailov V. D, Aitova A. A., Likhobabina D. A., Sutemieva J. A. , Frolova S. R. , Ruppel L. E. , Minakov D. A. , Suvorov N. V. , Ostroverkhov P. V. , Nikolaev M, Tsvelaya V. A. , Agladze K. I. , Grin M. A. / Azobenzene-Based Voltage-Gated Sodium Channel Blockers with Light-Controlled Local Anesthetic and Antiarrhythmic Activity / CELL BIOPHYSICS 2024 69 : 485–503
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Evlanenkov K, Nikolaev M, Potapjeva N, Bolshakov K, Tikhonov D / Probing the Proton-Gated ASIC Channels Using Tetraalkylammonium Ions / Biomolecules 2023 13(11) : 1631
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DOIPubMed
Nikolaev M, Tikhonov D / Light-Sensitive Open Channel Block of Ionotropic Glutamate Receptors by Quaternary Ammonium Azobenzene Derivatives / Int J Mol Sci 2023 24(18) : 13773
DOIPubMed
DOIPubMed
Kuzmenkov A, Peigneur S, Nasburg J, Mineev K, Nikolaev M, PinheiroJunior E, Arseniev A, Wulff H, Tytgat J, Vassilevski / Apamin structure and pharmacology revisited / Front Pharmacol 2022 174 : 977440
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Nikolaev M, Strashkov D, Ryazantsev M, Tikhonov D / Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors / Eur J Pharmacol 2022 16
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Nikolaev M, Чижов А. В., Tikhonov D / Molecular mechanisms of action determine inhibition of paroxysmal depolarizing shifts by NMDA receptor antagonists in rat cortical neurons / Neuropharmacology 2021 184 : 108-443
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DOIPubMed
Nikolaev M, Strashkov D, Ryazantsev M, Tikhonov D / Optical Control of NMethyldaspartate Receptors by Azobenzene Quaternary Ammonium Compounds / Acs Chem Neurosci 2021 12(18) : 3347-3357
DOIPubMed
DOIPubMed
Nikolaev M, Strashkov D, Ryazantsev M, Tikhonov D / Optical Control of N-Methyl- d -aspartate Receptors by Azobenzene Quaternary Ammonium Compounds / ACS Chem Neurosci 2021 Sep 15; 12(18) : 3347-3357
DOIPubMed
DOIPubMed
Nikolaev M / Effects of Antagonists of Different Types of NMDA Receptor on Evoked Responses of Pyramidal Neurons in Rat Cerebral Cortex Slices / Neuroscience and Behavioral Physiology 2020 50(4) : 493–499
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Føns S, Ledsgaard L, Nikolaev M, Vassilevski A, Sørensen C, Chevalier M, Fiebig M, Laustsen A / Discovery of a Recombinant Human Monoclonal Immunoglobulin G Antibody Against α-Latrotoxin From the Mediterranean Black Widow Spider ( Latrodectus tredecimguttatus) / Front. Immunol 2020 11 : 587825
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DOIPubMed
Nikolaev M, Komarova M, Tikhonova T, Korosteleva A, Potapjeva N, Tikhonov D / Modulation of Proton-Gated Channels by Antidepressants / ACS Chem Neurosci 2019 Mar 20; 10(3) : 1636-1648
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Komarova M, Potapjeva N, Nikolaev M / Non-Competitive but pH-Dependent Action of SB-366791 on Proton-Induced Activation of TRPV1 Receptors / Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology 2018 12 : 107–113
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Nikolaev M, Dorofeeva N, Komarova M, Korolkova Yu, Andreev Ya, Mosharova I, Grishin E, Tikhonov D, Kozlov S / TRPV1 activation power can switch an action mode for its polypeptide ligands / PLOS One 2017 12(5) : e0177077
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Barygin O, Komarova M, Tikhonova T, Korosteleva A, Nikolaev M, Magazanik L, Tikhonov D / Complex action of tyramine, tryptamine and histamine on native and recombinant ASICs / Channels (Austin) 2017 Nov 2; 11(6) : 648-659
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