Belinskaia D

Belinskaia D

Belinskaia

Daria A.

PhD

OrcID:  0000-0002-7850-8555
ResearcherID:  J-7098-2018
Research Gate:  Daria_Belinskaia
Scopus ID:  9244519100
eLibrary ID:  142269
E-Mail:  d_belinskaya@mail.ru

Area of scientific interests: the mechanisms of the development and management of chronic neuropathic pain and itch, the analgesic effect of psychotropic drugs, modeling the interaction of drugs and xenobiotics with their molecular targets using the computer simulation methods.
Key scientific results over the past 5 years: with the help of molecular docking and molecular dynamics methods, the interaction of the psychotropic drugs having analgesic and antipruritic activity with the N-methyl-D-aspartate receptor (NMDAR) and sodium-calcium exchanger (NCX) has been studied. The amino acids involved in the binding of the drugs have been found, the structural characteristics of the ligands that are responsible for the effectiveness of their interaction with NMDAR and NCX have been determined. The efficacy of the binding of the drugs to NMDAR and NCX has been shown to correlate with the strength of their analgesic/antipruritic activity and the severity of the side effects.

Articles

Korf E, Belinskaia D, Glotov AS, Glotov OS, Novokovich YS, Korostin DO, Rebrikov DV, Dudek SM, Goncharov N, Danilov SM / ACE-dependent Alzheimer disease: Further assessment of the impact of ACE mutations on blood ACE levels / Bba-Mol Basis Dis 2025 1871 : 167817
DOIPubMed
Belinskaia D, Savelieva EI / Search for Possible Conjugation Sites of Electrophiles with Biomolecules by Molecular Modeling / Russ J Bioorg Chem+ 2025 51() : 1320–1338
DOIeLibrary
Krivorotov DV, Belinskaia D, Smirnov AS, Suslonov VV, Goncharov N, Kuznetsov VA / In Silico Evaluation of the Effect of Geometrical Configuration and Charge of Opioid Antagonists on Their Binding to Receptors / Biochemistry (Moscow) Supplement. Series A: Membrane and Cell Biology 2025 19(3) : 303-317
DOIeLibrary
Voronina P, Belinskaia D, Samodurova K, Goncharov N / Esterase Profile: Structural, Functional and Evolutionary Aspects of Human and Animal Blood Esterases / J Evol Biochem Phys+ 2025 61(6) : 1952–1983
DOIeLibrary
Goncharov N, Savelieva EI, Koneva TA, Gustyleva LK, Vasilieva IA, Belyakov MV, Voitenko N, Belinskaia D, Korf E, Jenkins RO / Characteristics of the Fatty Acid Composition in Elderly Patients with Occupational Pathology from Organophosphate Exposure / Diagnostics 2025 15(24) : 3246
DOIPubMed
Goncharov N, Popova , Kudryavtsev I, Golovkin A, Savitskaya I, Avdonin P, Korf E, Voitenko N, Belinskaia D, Serebryakova M, Matveeva N, Gerlakh N, Anikievich N, Gubatenko M, Dobrylko I, Trulioff A, Aquino A, Jenkins R, Avdonin P / Immunological Profile and Markers of Endothelial Dysfunction in Elderly Patients with Cognitive Impairments / Int J Mol Sci 2024 25 : 1888
DOIPubMed
Andreeva-Gateva P, Hristov M, Strokova-Stoilova M, Ivanova N, Sabit Z, Surcheva S, Beliakov M, Karakashev G, Sukhov I, Belinskaia D, Shestakova N / Therapeutic potential of orally applied KB-R7943 in streptozotocin-induced neuropathy in rats / Heliyon. 2024 10(6) : e27367
DOIPubMed
Belinskaia D, Shestakova N / Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data / Biochemistry Moscow 2024 89 : 507–522
DOI
Belinskaia D, Jenkins, R.O., Goncharov N / Molecular Basis for the Involvement of Mammalian Serum Albumin in the AGE/RAGE Axis: A Comprehensive Computational Study / Int. J. Mol. Sci 2024 25 : 3204
DOIPubMed
Belinskaia D, Jenkins R, Goncharov N / Serum Albumin in Health and Disease: From Comparative Biochemistry to Translational Medicine / Int J Mol Sci 2023 24(18) : 13725
DOIPubMed
Goncharov N, Avdonin P, Voitenko N, Voronina P, Popova P, Novozhilov A, Blinova M, Popkova V, Belinskaia D, Avdonin P / Searching for New Biomarkers to Assess COVID-19 Patients: A Pilot Study / Metabolites 2023 13(12) : 1194
DOIPubMed
Belinskaia D, Goncharov N, Goncharov N / Structure-Dependent Mechanism of Organophosphate Release from Albumin and Butyrylcholinesterase Adducts When Exposed to Fluoride Ion: A Comprehensive In Silico Study" / International Journal of Molecular Sciences 2023 24(19) : 14819
DOIPubMed
Belinskaia D, Goncharov N / Interaction of Glycated Albumin with Receptor for Glycation End Products According to Molecular Modeling Data. / J Evol Biochem Phys 2023 59 : 2267–2284
DOI
Belinskaia D, Voronina P, Krivorotov D, Jenkins R / Anticholinesterase and Serotoninergic Evaluation of Benzimidazole–Carboxamides as Potential Multifunctional Agents for the Treatment of Alzheimer’s Disease" / Pharmaceutics 2023 15(8) : 2159
DOI
Belinskaia D, Voronina P, Popova P, Voitenko N, Shmurak V, Vovk M, Baranova T, Batalova A, Korf E, Avdonin P, Jenkins R, Goncharov N / Albumin Is a Component of the Esterase Status of Human Blood Plasma / International Journal of Molecular Sciences 2023 24(12) : 10383
DOI
Belinskaia D, Savelieva E, Karakashev G, Orlova O, Leninskii M, Khlebnikova N, Shestakova N, Kiskina A / Investigation of Bemethyl Biotransformation Pathways by Combination of LC-MS/HRMS and In Silico Methods / Int J Mol Sci. 2021 22(16) : 9021
DOI
Belinskaia D, Voronina P, Batalova A, Goncharov N / Serum Albumin Encyclopedia / Encyclopedia 2021 1(1) : 65-75
DOI
Belinskaia D, Voronina P, Shmurak V, Jenkins R, Goncharov N / Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties / International Journal of Molecular Sciences 2021 22(19) : 10318
DOI
Uniyal A, Shantanu P, Vaidya S, Belinskaia D, Shestakova N, Kumar R, Singh S, Tiwari V / Tozasertib Attenuates Neuropathic Pain by Interfering with Aurora Kinase and KIF11 Mediated Nociception / ACS Chem Neurosci 2021 12(11) : 1948-1960
DOI
Belinskaia D, Savelieva E, Karakashev G, Orlova O, Leninskii M, Khlebnikova N, Shestakova N, Kiskina A / Investigation of Bemethyl Biotransformation Pathways by Combination of LC–MS/HRMS and In Silico Methods / International Journal of Molecular Sciences 2021 22(16) : 9021
DOI
Belinskaia D, Voronina P, Vovk M, Shmurak V, Batalova A, Jenkins R, Goncharov N / Esterase Activity of Serum Albumin Studied by 1H NMR Spectroscopy and Molecular Modelling / International Journal of Molecular Sciences 2021 14(19) : 10593
DOI
Goncharov N, Belinskaia D, Shmurak V, Korf E, Jenkins R, Avdonin P / Experimental modeling for delayed effects of organophosphates / Handbook of the Toxicology of Chemical Warfare Agents 2020 3rd ed. : 843-851
DOI
Belinskaia D, Voronina P, Shmurak V, Vovk M, Batalova A, Jenkins R, Goncharov N / The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin / Antioxidants 2020 258(10) : 555-6319-327-824-966
DOI
Belinskaia D, Belinskaia M, Barygin O, Vanchakova N, Shestakova N / Psychotropic drugs for the management of chronic pain and itch / Pharmaceuticals (Basel) 2019 12(2) : 99
DOIwww
Belinskaia D, Batalova A, Goncharov N / The effect of resveratrol on binding and esterase activity of human and rat albumin / J Evol Biochem Phys 2019 55 : 174–183
DOI
Belinskaia D, Avdonin PP, Avdonin PV, Jenkins R, Goncharov N / Rational in silico design of aptamers for organophosphates based on the example of paraoxon / Comput. Biol. Chem. 2019 80 : 452-462
DOI
Stepanenko Yu, Boikov S, Sibarov D, Abushik P, Vanchakova N, Belinskaia D, Shestakova N, Antonov S / Dual action of amitriptyline on NMDA receptors: enhancement of Ca-dependent desensitization and trapping channel block / Sci Rep 2019 Dec 19; 9(1) : 19454
DOIPubMedwww
Barygin O, Nagaeva E, Tikhonov D, Belinskaia D, Vanchakova N, Shestakova N / Inhibition of the NMDA and AMPA receptor channels by antidepressants and antipsychotics / Brain Research 2017 1660 : 58-66
DOI
Goncharov N, Belinskaia D, Shmurak V, Terpilowski M, Jenkins R, Avdonin P / Serum albumin binding and esterase activity: mechanistic interactions with organophosphates / Molecules 2017 22(7) : E 1201
DOIwww

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