Zhorov B

Zhorov B

Zhorov

Boris S.

PhD, D.Sc., Professor

ResearcherID:  V-8072-2019
Research Gate:  Boris-Zhorov
Scopus ID:  7006979294
eLibrary ID:  85476

Molecular modeling of ion channels and their complexes with drugs and toxins. Author of the ZMM program for molecular modeling (www.zmmsoft.ca). Author of over three hundred publications, of which 251 are indexed in WoS and 142 are indexed in PUBMED (https://pubmed.ncbi.nlm.nih.gov/?term=zhorov+b). H-index 31 (WoS).

Articles

Zaucha J, Heinzinger M, Kulandaisamy A, Kataka E, Salvador Ó, Popov P, Rost B, Gromiha M, Zhorov B, Frishman D / Mutations in transmembrane proteins: diseases, evolutionary insights and prediction / Briefings in Bioinformatics 2021 22(3) : 1–16
DOI
Zhorov B / Possible Mechanism of Ion Selectivity in Eukaryotic Voltage-Gated Sodium Channels / J. Phys. Chem. B. 2021 125(8) : 2074-2088
DOI
Zhorov B / Structures of sodium and calcium channels with ligands / Journal of Evolutionary Biochemistry and Physiology 2021 57 : 337–353
DOI
Zhorov B, Du Y, Song W, Luo N, Gordon D, Gurevitz M, Dong K / Mapping binding site of scorpion β-toxins on an insect sodium channel / Biochem. J. 2021 478 : 2843–2869
DOI
Tikhonov D, Zhorov B / Crystal and Cryo-EM Structures of P-loop Channels with Drugs / IJMS 2021 22 : 8143
DOI
Tarnovskaya S, Kostareva A, Zhorov B / L-type Calcium Channel: Predicting Pathogenic / Likely Pathogenic Status for Variants of Uncertain Clinical Significance / Membranes 2021 11 : 599
DOI
Zaitseva A, Boitsov A, Kostareva A, Zhorov B / Possible interactions of extracellular loop IVP2-S6 with voltage-sensing domain III in cardiac sodium channel / Front. Pharmacol. 2021 12 : 742508
DOI
Korkosh V, Zaitseva A, Kostareva A, Zhorov B / Intersegment Contacts of Potentially Damaging Variants of Cardiac Sodium Channel / Front. Pharmacol. 2021 12 : 756415
DOI
Tikhonov D, Zhorov B / Intersegment contacts determine geometry of the open and closed states in P-loop channels / J Biomol Struct Dyn. 2020 38(4) : 1012-1027
DOI
Tarnovskaya S, Korkosh V, Zhorov B, Frishman D / Predicting novel disease mutations in the cardiac sodium channel / Biochemical and Biophysical Research Communications 2020 521(3) : 603-611
DOI
Chen M, Du Y, Nomura Y, Zhorov B, Dong K / Chronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti / Archives Insect Biochem. Physiol. 2020 104(2) : e21686
DOI
Yan R, Zhou Q, Xu Z, Zhu G, Dong K, Zhorov B, Chen M / Three sodium channel mutations from Aedes albopictus confer resistance to Type I, but not Type II pyrethroids / Insect Biochem Mol. Biol. 2020 123 : 103411
DOI
Tikhonov D, Zhorov B / The pore domain in glutamate-gated ion channels: structure, drug binding and similarity with potassium channels / BBA-biomembranes 2020 1862(10) : 183401
DOI
Tikhonov D, Lin L, Yang D, Yuchi Z, Zhorov B / Phenylalkylamines in calcium channels: Computational analysis of experimental structures / J Computer-Aided Mol Design 2020 34(11) : 1157-1169
DOI
Tikhonov D, Zhorov B / Molecular modeling in studies of ion channels and their modulation by ligands / Russian J. Physiol. 2019 105 : 1333–1348
DOI
Finol-Urdaneta R, McArthur J, Gaudet R, Tikhonov D, Zhorov B, French R / Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated Na+ channels / J. Gen. Physiol. 2019 151(2) : 186-199
DOIPubMed
Korkosh V, Kiselev A, Mikhaylov E, Kostareva A, Zhorov B / Atomic mechanisms of Timothy syndrome-associated mutations in calcium channel Cav1.2 / Frontiers Physiol. 2019 10(335) : 1-23
DOI
Chen M, Wu S, Du Y, Nomura Y, Zhu G, Zhorov B, Dong K / Molecular evidence of sequential evolution of DDT-and pyrethroid-resistant sodium channel in Aedes aegypti / PLOS Neglected Tropical Diseases 2019 13(6) : e0007432
DOI
Finol-Urdaneta R, McArthur J, Korkosh V, Huang S, McMaster D, Glavica R, Tikhonov D, Zhorov B, French R / Extremely high-affinity block of bacterial voltage-gated sodium channels by µ-conotoxin PIIIA / Marine Drugs 2019 17 : 510
DOIPubMed
Du Y, Tikhonov D, Nomura Y, Dong K, Zhorov B / Mutational analysis of state-dependent contacts in the pore module of eukaryotic sodium channels / Arch Biochem Biophys. 2018 652 : 59-79
DOI
Fehrentz T, Huber F, Vrielink N, Bruegmann T, Frank J, Fine N, Malan D, Danzl D, Tikhonov D, Hell S, Sasse P, Hodson D, Zhorov B, Klöcker N, Trauner D / Optical control of L-type Ca2+ channels using a diltiazem photoswitch / Nature Chem Biol 2018 14 : 764-767
DOIPubMed
Chen M, Du Y, Zhu G, Matsuda K, Zhorov B, Dong K / Action of six pyrethrins from the plant insecticide pyrethrum on cockroach sodium channels / Pesticide Biochem. Physiol. 2018 151 : 82-89
DOI
Tikhonov D, Zhorov B / Predicting structural details of the sodium channel pore basing on animal toxin studies / Frontiers Pharmacol 2018 9(880) : 1-14
DOIPubMed
Zhorov B / Structural models of ligand binding in sodium channels / Handbook Experim. Pharmacol. 2018 246 : 251-269
DOI
Zhorov B, Dong K / Elucidation of pyrethroid and DDT receptor sites in the voltage-gated sodium channel / Neurotoxicology 2017 60 : 171-177
DOI
Tikhonov D, Zhorov B / Mechanism of sodium channel block by local anesthetics, antiarrhythmics and anticonvulsants / J Gen Physiol. 2017 149 : 465-481
DOIPubMed
Maleeva G, Peiretti F, Zhorov B, Bregestovski P / Voltage-dependent inhibition of glycine receptor channels by niflumic acid / Frontiers Mol. Neurosci. 2017 10 : 125
DOI
Tikhonov D, Zhorov B / Conservation and variability of the pore-lining helices in P-loop channels / Channels 2017 11(6) : 660-67
DOI
Wu S, Nomura Y, Du Y, Zhorov B, Dong K / Molecular basis of selective resistance of the bumblebee BiNav1 sodium channel to tau-fluvalinate / PNAS USA 2017 114 : 12922-12927
DOI