Kochkina E

Kochkina E


Ekaterina G.

ResearcherID:  AAN-7383-2020
Research Gate:  Ekaterina_Kockina
Scopus ID:  8234356700
eLibrary ID:  128888

Area of research – studies of molecular basis of brain activity and its biochemical and physiological regulation in normal development, aging and pathologies (prenatal hypoxia, brain ischemia, neurodegenerative diseases, in particular Alzheimer’s disease) and the role in these processes of acetyl and butyrylcholinesterases, as well as of insulin-degrading enzyme and neprilysin which catabolize amyloid Aβ peptide. It was shown that prenatal hypoxia leads to a decrease in the activities of cholinesterases and neprilysin in rat brain tissues and blood plasma. Levels of activity of these enzymes also correlated with the scores for cognitive deficit and Alzheimer’s disease. Research is carried out using zootropic and cell models by the methods of molecular biology (immunoblotting, rt-PCR, fluorescent methods).


Zhuravin I, Dubrovskaya N, Vasiliev D, Kozlova D, Kochkina E, Tumanova N, Nalivaeva N / Regulation of Neprilysin Activity and Cognitive Functions in Rats After Prenatal Hypoxia / Neurochemical Research 2019 44(6) : 1387-1398
Kozlova D, Kochkina E, Dubrovskaya N, Zhuravin I / Effect of Prenatal Hypoxia on Cholinesterase Activity in Blood Serum of Rats / Neurochemical Journal 2018 April. 12(2) : 159–167