Basova I

Investigation of the catalytic activity of monoamine oxidase (MAO) of the liver and various parts of the brain in various species of aquatic organisms and terrestrial animals. Comparative substrate – inhibitor analysis of the liver and brain enzyme in marine invertebrates. Study of deaminating properties (MAO) of the liver in rats with metabolic syndrome and obesity of the liver. A comparative study of the activity (MAO) of rat liver using drugs that reduce the effect of a high-carbohydrate-fat diet on glucose metabolism. The results of the studies confirmed the high activity and substrate – inhibitory specificity of form A monoamine oxidase in aquatic animals, and the low activity of form B. Studies of the liver of rats with an induced high carbohydrate-fat diet showed an increase in MAO-B activity, a decrease in MAO-A activity and an unusual physiological norm, transformation enzyme into diamine oxidase.