Bakhtyukov A
Bakhtyukov
Andrey A.
OrcID: 0000-0002-2060-2020
ResearcherID: AAN-1834-2020
Research Gate: Andrey_Bakhtyukov
Scopus ID: 57191163820
eLibrary ID: 912603
E-Mail: bahtyukov@gmail.com
My current research interest is the study of the hypothalamic-pituitary-gonadal axis and its functioning in normal conditions and in the course of metabolic dysfunctions using the Wistar rat model. The main goal is to study the mechanisms of action of the diabetes mellitus on steroidogenesis in the rat testes and study the approaches for its correcting. Among the approaches are investigating of well-known antidiabetic drugs, as well as new allosteric regulators of G-protein-coupled receptors. The most efforts are focused on the study of allosteric regulators of luteinizing and thyroid stimulating hormone receptors. At the work is used such biochemical methods such as ELISA and real-time PCR to study the biological activity of drugs and intracellular signaling pathways.
Monographs and chapters
Shpakov A, Derkach K, Bakhtyukov A, Dar’in D / The low molecular weight ligands of the gonadotropin receptors as the new generation of the regulators of the reproductive functions and steroidogenesis // In: “Innovations in Assisted Reproduction Technology” (Eds. N. Sharma, S. Chakrabarti) / Rijeka, Croatia / Intech Open Access Publisher / 2019 / 1–21
ISBN: 978-1-83880-548-7
DOI
ISBN: 978-1-83880-548-7
DOI
Shpakov A, Roy V, Bakhtyukov A, Derkach K / The adipokines-mediated regulation of the testosterone production and its changes in metabolic disorders. Chapter 5 // In: Advances in Medicine and Biology, Vol. 144 (Ed. by Leon V. Berhardt) / NY / Nova Science Publishers, Inc. / 2019 / 1-85 ID: 58456
ISBN: 978-1-53615-842-7
ISBN: 978-1-53615-842-7
Shpakov A, Ryzhov Ju, Bakhtyukov A, Derkach K / The regulation of the male hypothalamic-pituitary-gonadal axis and testosterone production by adipokines (Chapter 2) // In: Advances in Testosterone Action (Ed. by M. Estrada) / Rijeka, Croatia / Intech Open Access Publisher / 2018 / 25–57
ISBN: 978-953-51-6241-4
DOI
ISBN: 978-953-51-6241-4
DOI
Articles
Derkach K, Gureev M, Babushkina A, Mikhaylov V, Zakharova I, Bakhtyukov A, Sorokoumov V, Novikov A, Krasavin M, Shpakov A, Balova I / Dual PTP1B/TC-PTP Inhibitors: Biological Evaluation of 3-(Hydroxymethyl)cinnoline-4(1H)-Ones / Int J Mol Sci 2023 24(5) : 4498
DOIPubMed
DOIPubMed
Derkach K, Lebedev I, Morina I, Bakhtyukov A, Pechalnova A, Sorokoumov V, Kuznetsova V, Romanova I, Shpakov A / Comparison of Steroidogenic and Ovulation-Inducing Effects of Orthosteric and Allosteric Agonists of Luteinizing Hormone/Chorionic Gonadotropin Receptor in Immature Female Rats / Int J Mol Sci 2023 24(23) : 16618
DOIPubMed
DOIPubMed
Bakhtyukov A, Derkach K, Sorokoumov V, Stepochkina A, Romanova I, Morina I, Zakharova I, Bayunova L, Shpakov A / The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis / International Journal of Molecular Sciences 2021 23(1) : 198
DOI
DOI
Bakhtyukov A, Derkach K, Gureev M, Darin D, Sorokoumov V, Romanova I, Morina I, Stepochkina A, Shpakov A / Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats / International Journal of Molecular Sciences 2020 21(20) : E7493
DOI
DOI
Derkach K, Zakharova I, Zorina I, Bakhtyukov A, Romanova I, Bayunova L, Shpakov A / The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect / PLOS One 2019 14(3) : e0213779
DOIPubMed
DOIPubMed
Bakhtyukov A, Derkach K, Dar’in D, Stepochkina A, Shpakov A / A low molecular weight agonist of the luteinizing hormone receptor stimulates adenylyl cyclase in the testicular membranes and steroidogenesis in the testes of rats with type 1 diabetes / Biochemistry (Moscow). Suppl. Series A: Membrane and Cell Biology 2019 13(4) : 301–309
DOI
DOI
Bakhtyukov A, Derkach K, Dar’in D, Shpakov A / Conservation of steroidogenic effect of the low-molecular-weight agonist of luteinizing hormone receptor in the course of its long-term administration to male rats / Dokl. Biochem. Biophys. 2019 484(1) : 78–81
DOIPubMed
DOIPubMed
