Vataev S.I. performed studies the effects of electrical stimulation of the central nucleus of the inferior colliculus and the oral reticular nucleus of the pons on the generation and formation of convulsive manifestations and on the organization of sleep in Krushinskii-Molodkina rats, which have an inherited predisposition to audiogenic seizures.
He studied the changes in brain electrical activity patterns in rats with different susceptibility to seizures in lithium-pilocarpine model of status epilepticus. Chronic experiments on Wistar and Krushinskii–Molodkina rats, which have an inherited predisposition to audiogenic convulsions, addressed the effects of preliminary administration of NMDA glutamate receptor channel blockers on brain electrical activity on development of status epilepticus (SE) induced by pilocarpine. The data provide evidence that blockade of NMDA receptors did not prevent the typical development of pilocarpine-induced SE, though duration was significantly reduced.
The results of this work will clarify the direction of the search for drugs for anticonvulsant therapy