Shpakov A
Shpakov
Alexander O
Professor, Doctor of Biology
OrcID: 0000-0002-4293-3162
ResearcherID: R-6581-2016
Research Gate: Alexander-Shpakov-Lab
Scopus ID: 35231150500
eLibrary ID: 87662
E-Mail: alex_shpakov@list.ru
A leading expert in the field of the molecular endocrinology, the biochemistry of hormones and the neurochemistry. The main areas of scientific activity are the study of the molecular basis of the functioning of the hormonal signaling systems in norm and in the metabolic and endocrine diseases, the deciphering and investigation of molecular mechanisms of the action of hormones, neurotransmitters, adipokines and growth factors on the nervous, endocrine, cardiovascular and other systems, as well as the development, the study of mechanisms and targets of action and the preclinical studies of allosteric regulators and modulators of the hypothalamic-pituitary system, which are belonging to the classes of the heterocyclic and peptide compounds. The author of 400 articles and reviews in peer-reviewed journals indexed in the Web of Sciences and Scopus databases, 12 chapters in reputable international books, and nine monographs.
Monographs and chapters
Shpakov A, Derkach K, Bakhtyukov A, Dar’in D / The low molecular weight ligands of the gonadotropin receptors as the new generation of the regulators of the reproductive functions and steroidogenesis // In: “Innovations in Assisted Reproduction Technology” (Eds. N. Sharma, S. Chakrabarti) / Rijeka, Croatia / Intech Open Access Publisher / 2019 / 1–21
ISBN: 978-1-83880-548-7
DOI
ISBN: 978-1-83880-548-7
DOI
Shpakov A, Roy V, Bakhtyukov A, Derkach K / The adipokines-mediated regulation of the testosterone production and its changes in metabolic disorders. Chapter 5 // In: Advances in Medicine and Biology, Vol. 144 (Ed. by Leon V. Berhardt) / NY / Nova Science Publishers, Inc. / 2019 / 1-85 ID: 58456
ISBN: 978-1-53615-842-7
ISBN: 978-1-53615-842-7
Shpakov A, Ryzhov Ju, Bakhtyukov A, Derkach K / The regulation of the male hypothalamic-pituitary-gonadal axis and testosterone production by adipokines (Chapter 2) // In: Advances in Testosterone Action (Ed. by M. Estrada) / Rijeka, Croatia / Intech Open Access Publisher / 2018 / 25–57
ISBN: 978-953-51-6241-4
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ISBN: 978-953-51-6241-4
DOI
Shpakov A / The contribution of changes in adenylyl cyclase signaling system of the brain and myocardium to etiology and pathogenesis of diabetes mellitus. // Chapter 12 In: Evolutionary Physiology and Biochemistry – Advances and Perspectives / Rijeka, Croatia / Intech Open Access Publisher / 2018 / P: 153–166
ISBN: 978-953-51-3858-7
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ISBN: 978-953-51-3858-7
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Shpakov A / Heterotrimeric G Proteins / Elsevier / Reference Module in Life Sciences / 2017 /
ISBN: 978-0-12-809633-8
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ISBN: 978-0-12-809633-8
DOI
Articles
Zakharova I, Bayunova L, Zorina I, Sokolova T, Shpakov A, Avrova N / Insulin and α-Tocopherol Enhance the Protective Effect of Each Other on Brain Cortical Neurons under Oxidative Stress Conditions and in Rat Two-Vessel Forebrain Ischemia/Reperfusion Injury / International Journal of Molecular Sciences 2021 22(21) : 11768
DOI
DOI
Bakhtyukov A, Derkach K, Sorokoumov V, Stepochkina A, Romanova I, Morina I, Zakharova I, Bayunova L, Shpakov A / The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis / International Journal of Molecular Sciences 2021 23(1) : 198
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DOI
Annie L, Jeremy M, Gurusubramanian G, Derkach K, Shpakov A, Roy V / Effect of metformin on testicular expression and localization of leptin receptor and levels of leptin in the diabetic mice / Molecular Reproduction and Development 2020 May; 87(5) : 620-629
DOIPubMed
DOIPubMed
Bakhtyukov A, Derkach K, Gureev M, Darin D, Sorokoumov V, Romanova I, Morina I, Stepochkina A, Shpakov A / Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats / International Journal of Molecular Sciences 2020 21(20) : E7493
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DOI
Zakharova I, Sokolova T, Bayunova L, Zorina I, Rychkova M, Shpakov A, Avrova N / Protective Effect of Insulin on Rat Cortical Neurons in Oxidative Stress and Its Dependence on the Modulation of Akt, GSK-3beta, ERK1/2, and AMPK Activities / International Journal of Molecular Sciences 2019 Jul 29;20(15) : E3702
DOIPubMed
DOIPubMed
Derkach K, Zakharova I, Zorina I, Bakhtyukov A, Romanova I, Bayunova L, Shpakov A / The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect / PLOS One 2019 14(3) : e0213779
DOIPubMed
DOIPubMed
Derkach K, Bondareva V, Perminova A, Shpakov A / C-peptide and insulin during combined intranasal administration improve the metabolic parameters and activity of the adenylate cyclase system in the hypothalamus, myocardium, and epididymal fat of rats with type 2 diabetes / Cell Tissue Biol. 2019 13(3) : 228–236
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Derkach K, Bondareva V, Shpakov A / Regulatory effects of intranasal C-peptide and insulin on thyroid and androgenic status of male rats with moderate type 1 diabetes mellitus / J Evol Biochem Phys 2019 55(6) : 493–496
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DOI
Bakhtyukov A, Derkach K, Dar’in D, Stepochkina A, Shpakov A / A low molecular weight agonist of the luteinizing hormone receptor stimulates adenylyl cyclase in the testicular membranes and steroidogenesis in the testes of rats with type 1 diabetes / Biochemistry (Moscow). Suppl. Series A: Membrane and Cell Biology 2019 13(4) : 301–309
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DOI
Bakhtyukov A, Derkach K, Dar’in D, Shpakov A / Conservation of steroidogenic effect of the low-molecular-weight agonist of luteinizing hormone receptor in the course of its long-term administration to male rats / Dokl. Biochem. Biophys. 2019 484(1) : 78–81
DOIPubMed
DOIPubMed
Sukhov I, Lebedeva M, Zakharova I, Derkach K, Bayunova L, Zorina I, Avrova N, Shpakov A / Intranasal administration of insulin and gangliosides improves spatial memory in rats with neonatal type 2 diabetes mellitus / Bull. Exp. Biol. Med. 2019 168(3) : 317-320
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DOI
Zakharova I, Sokolova T, Bayunova L, Zorina I, Rychkova M, Shpakov A, Avrova N / The Protective Effect of Insulin on Rat Cortical Neurons in Oxidative Stress and Its Dependence on the Modulation of Akt, GSK-3beta, ERK1/2, and AMPK Activities / International Journal of Molecular Sciences 2019 20(15) : E3702
DOI
DOI
Zorina I, Fokina E, Zakharova I, Bayunova L, Shpakov A / Features of the changes in lipid peroxidation and activity of Na+/K+-ATPase in the brain of the aged rats in the conditions of two-vessel cerebral ischemia/reperfusion / Advances in Gerontology 2019 32(6) : 941-947
PubMed
PubMed
Romanova I, Derkach K, Mikhrina A, Sukhov I, Mikhailova E, Shpakov A / The leptin, dopamine and serotonin receptors in hypothalamic POMC-neurons in normal and obese rodents / Neurochemical Research 2018 43(4) : 821–837
DOIPubMed
DOIPubMed
Derkach K, Bondareva V, Shpakov A / Coadministration of intranasally delivered insulin and proinsulin C-peptide to rats with the types 1 and 2 diabetes mellitus restores their metabolic parameters / Advances in Gerontology 2018 8(2) : 139–146
DOIPubMed
DOIPubMed
Shpakov A, Derkach K / Molecular Mechanisms of the Effects of Metformin on the Functional Activity of Brain Neurons / Neurosci. Behav. Physiol. 2018 V. 48. №. 8 : 969–977
DOIeLibrary
DOIeLibrary
Derkach K, Zakharova I, Romanova I, Zorina I, Mikhrina A, Shpakov A / Metabolic parameters and functional state of hypothalamic signaling systems in Ay mice with genetic predisposition to obesity and the effect of metformin / Dokl. Biochem. Biophys. 2017 477(1) : 377–381
DOIPubMed
DOIPubMed
Shpakov A / Pharmacological approaches for correction of thyroid dysfunctions in diabetes mellitus / Biomedical Chemistry 2017 11(4) : 349–362
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DOI
Derkach K, Ivantsov A, Sukhov I, Shpakov A / Restoration of hypothalamic signaling systems as a cause of improved metabolic parameters in rats with neonatal diabetes model during treatment with bromocryptine mesylate / Cell Tissue Biol. 2017 V.11. №3 : 234–241
DOI
DOI
Derkach K, Ivantsov A, Chistyakova O, Sukhov I, Buzanakov D, Kulikova A, Shpakov A / Intranasal insulin restores metabolic parameters and insulin sensitivity in rats with metabolic syndrome / Bull. Exp. Biol. Med. 2017 V. 163. № 2 : 184-189
DOIPubMed
DOIPubMed
Shpakov A, Derkach K, Zharova O, Shpakova E / The functional activity of the adenylyl cyclase system in the brain of rats with metabolic syndrome that induced by immunization with the 11–25 peptide of the melanocortin receptor of the fourth type / Neurochemical Journal 2015 9(1) : 29–38
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DOI
Derkach K, Shpakova E, Titov A, Shpakov A / Intranasal and intramuscular administration of lysine-palmitoylated peptide 612-627 of thyroid-stimulating hormone receptor increases the level of thyroid hormones in rats / International Journal of Peptide Research and Therapeutics 2015 21(3) : 249–260
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DOI
Derkach K, Bogush I, Berstein L, Shpakov A / The influence of intranasal insulin on hypothalamic-pituitary-thyroid axis in normal and diabetic rats / Hormone and Metabolic Research 2015 47(12) : 916–924
DOIPubMed
DOIPubMed
Derkach K, Bondareva V, Chistyakova O, Berstein L, Shpakov A / The effect of long-term intranasal serotonin treatment on metabolic parameters and hormonal signaling in rats with high-fat diet/low-dose streptozotocin-induced type 2 diabetes / Int. J. Endocrinol. 2015 2015 : 245459
DOIPubMed
DOIPubMed
