Derkach K

Derkach K

Derkach

Kira V.

PhD

OrcID:  0000-0001-6555-9540
ResearcherID:  AAN-1060-2020
Research Gate:  Kira_Derkach
Scopus ID:  6603743572
eLibrary ID:  83183
E-Mail:  derkatch_k@list.ru

A leading expert in the field of the molecular endocrinology and the biochemistry of hormones. The main areas of scientific activity are the study of the functional activity and the mechanisms of action of the hormonal and adipokynes-regulated signaling systems and their disturbances in diabetes mellitus and metabolic syndrome, the study of the molecular basis of the functioning of the gonadal and thyroid systems and the development of their low-molecular-weight regulators with the activity of agonists and antagonists, the investigation of the activity of hypothalamic signaling systems and the development of approaches for their correction using intranasally administered insulin and its combinations with other regulators of the hypothalamic signaling. The author of more than 160 articles and reviews in peer-reviewed journals indexed in the Web of Sciences and Scopus databases, 6 chapters in reputable international books, and three monographs.

Monographs and chapters

Shpakov A, Derkach K, Bakhtyukov A, Dar’in D / The low molecular weight ligands of the gonadotropin receptors as the new generation of the regulators of the reproductive functions and steroidogenesis // In: “Innovations in Assisted Reproduction Technology” (Eds. N. Sharma, S. Chakrabarti) / Rijeka, Croatia / Intech Open Access Publisher / 2019 / 1–21
ISBN: 978-1-83880-548-7
DOI
Shpakov A, Roy V, Bakhtyukov A, Derkach K / The adipokines-mediated regulation of the testosterone production and its changes in metabolic disorders. Chapter 5 // In: Advances in Medicine and Biology, Vol. 144 (Ed. by Leon V. Berhardt) / NY / Nova Science Publishers, Inc. / 2019 / 1-85 ID: 58456
ISBN: 978-1-53615-842-7
Shpakov A, Ryzhov Ju, Bakhtyukov A, Derkach K / The regulation of the male hypothalamic-pituitary-gonadal axis and testosterone production by adipokines (Chapter 2) // In: Advances in Testosterone Action (Ed. by M. Estrada) / Rijeka, Croatia / Intech Open Access Publisher / 2018 / 25–57
ISBN: 978-953-51-6241-4
DOI

Articles

Bakhtyukov A, Derkach K, Sorokoumov V, Stepochkina A, Romanova I, Morina I, Zakharova I, Bayunova L, Shpakov A / The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis / International Journal of Molecular Sciences 2021 23(1) : 198
DOI
Annie L, Jeremy M, Gurusubramanian G, Derkach K, Shpakov A, Roy V / Effect of metformin on testicular expression and localization of leptin receptor and levels of leptin in the diabetic mice / Molecular Reproduction and Development 2020 May; 87(5) : 620-629
DOIPubMed
Bakhtyukov A, Derkach K, Gureev M, Darin D, Sorokoumov V, Romanova I, Morina I, Stepochkina A, Shpakov A / Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats / International Journal of Molecular Sciences 2020 21(20) : E7493
DOI
Derkach K, Zakharova I, Zorina I, Bakhtyukov A, Romanova I, Bayunova L, Shpakov A / The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect / PLOS One 2019 14(3) : e0213779
DOIPubMed
Derkach K, Bondareva V, Perminova A, Shpakov A / C-peptide and insulin during combined intranasal administration improve the metabolic parameters and activity of the adenylate cyclase system in the hypothalamus, myocardium, and epididymal fat of rats with type 2 diabetes / Cell Tissue Biol. 2019 13(3) : 228–236
DOI
Derkach K, Bondareva V, Shpakov A / Regulatory effects of intranasal C-peptide and insulin on thyroid and androgenic status of male rats with moderate type 1 diabetes mellitus / J Evol Biochem Phys 2019 55(6) : 493–496
DOI
Bakhtyukov A, Derkach K, Dar’in D, Stepochkina A, Shpakov A / A low molecular weight agonist of the luteinizing hormone receptor stimulates adenylyl cyclase in the testicular membranes and steroidogenesis in the testes of rats with type 1 diabetes / Biochemistry (Moscow). Suppl. Series A: Membrane and Cell Biology 2019 13(4) : 301–309
DOI
Bakhtyukov A, Derkach K, Dar’in D, Shpakov A / Conservation of steroidogenic effect of the low-molecular-weight agonist of luteinizing hormone receptor in the course of its long-term administration to male rats / Dokl. Biochem. Biophys. 2019 484(1) : 78–81
DOIPubMed
Sukhov I, Lebedeva M, Zakharova I, Derkach K, Bayunova L, Zorina I, Avrova N, Shpakov A / Intranasal administration of insulin and gangliosides improves spatial memory in rats with neonatal type 2 diabetes mellitus / Bull. Exp. Biol. Med. 2019 168(3) : 317-320
DOI
Romanova I, Derkach K, Mikhrina A, Sukhov I, Mikhailova E, Shpakov A / The leptin, dopamine and serotonin receptors in hypothalamic POMC-neurons in normal and obese rodents / Neurochemical Research 2018 43(4) : 821–837
DOIPubMed
Derkach K, Bondareva V, Shpakov A / Coadministration of intranasally delivered insulin and proinsulin C-peptide to rats with the types 1 and 2 diabetes mellitus restores their metabolic parameters / Advances in Gerontology 2018 8(2) : 139–146
DOIPubMed
Shpakov A, Derkach K / Molecular Mechanisms of the Effects of Metformin on the Functional Activity of Brain Neurons / Neurosci. Behav. Physiol. 2018 V. 48. №. 8 : 969–977
DOIeLibrary
Derkach K, Zakharova I, Romanova I, Zorina I, Mikhrina A, Shpakov A / Metabolic parameters and functional state of hypothalamic signaling systems in Ay mice with genetic predisposition to obesity and the effect of metformin / Dokl. Biochem. Biophys. 2017 477(1) : 377–381
DOIPubMed
Derkach K, Ivantsov A, Sukhov I, Shpakov A / Restoration of hypothalamic signaling systems as a cause of improved metabolic parameters in rats with neonatal diabetes model during treatment with bromocryptine mesylate / Cell Tissue Biol. 2017 V.11. №3 : 234–241
DOI
Derkach K, Ivantsov A, Chistyakova O, Sukhov I, Buzanakov D, Kulikova A, Shpakov A / Intranasal insulin restores metabolic parameters and insulin sensitivity in rats with metabolic syndrome / Bull. Exp. Biol. Med. 2017 V. 163. № 2 : 184-189
DOIPubMed
Shpakov A, Derkach K, Zharova O, Shpakova E / The functional activity of the adenylyl cyclase system in the brain of rats with metabolic syndrome that induced by immunization with the 11–25 peptide of the melanocortin receptor of the fourth type / Neurochemical Journal 2015 9(1) : 29–38
DOI
Derkach K, Shpakova E, Titov A, Shpakov A / Intranasal and intramuscular administration of lysine-palmitoylated peptide 612-627 of thyroid-stimulating hormone receptor increases the level of thyroid hormones in rats / International Journal of Peptide Research and Therapeutics 2015 21(3) : 249–260
DOI
Derkach K, Bogush I, Berstein L, Shpakov A / The influence of intranasal insulin on hypothalamic-pituitary-thyroid axis in normal and diabetic rats / Hormone and Metabolic Research 2015 47(12) : 916–924
DOIPubMed
Derkach K, Bondareva V, Chistyakova O, Berstein L, Shpakov A / The effect of long-term intranasal serotonin treatment on metabolic parameters and hormonal signaling in rats with high-fat diet/low-dose streptozotocin-induced type 2 diabetes / Int. J. Endocrinol. 2015 2015 : 245459
DOIPubMed
Shpakov A, Derkach K, Berstein L / Brain signaling systems in the type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases / Future Science OA (FSO) 2015 1(3) : FSO25
DOIPubMed

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